A Delta flight from Cincinnati to Honolulu was diverted to San Francisco after a woman had a meltdown onboard. By "meltdown" I mean she smoked in the lavatory, got belligerent when confronted about it, then punched the pilot. The airlines tend to frown upon that kind of behavior. The passenger was removed at SFO and the flight carried on to Honolulu without incident.
Oddly enough, the only time I saw a woman get caught smoking on board was also on a flight to Honolulu. She was reprimanded sternly (as you might imagine) by cabin staff, and then given, no joke, 13 glasses of champagne so she would sleep for the remaining 8 hours to Honolulu. That did the trick.